World Health Organization guidelines promote an approach called “Option B+”, in which pregnant women who test positive for HIV are placed on lifelong antiretroviral therapy (ART) regardless of their clinical and immunological stage, both to support their health and prevent transmission of HIV to their infant. The “Option B+” study aimed to generate evidence on effective strategies for implementing Option B+ in resource-limited settings. This research, initiated in June 2012, was conducted in collaboration with the University of Washington and the Mozambique Ministry of Health’s Beira Operations Research Center (CIOB). The study began with a two-year formative phase, during which the study team developed an appropriate intervention based on stakeholder input collected through focus groups and structured interviews. This was followed by a one-year implementation using a stepped-wedge design to assess the effectiveness of a model that aims to “Option B+” adherence and retention in six large health centers in Manica and Sofala Province.
A complete description of the study and methodology can be found here.
This study is being supported by a grant from the National Institute of Child Health and Development.